Six Mile, South Carolina

Vacation Rentals in Six Mile, South Carolina

Discover 42 vacation rental properties in Six Mile. From 1 to 6 bedrooms. Average $602/night. 100% have pools.

42 verified listings Book securely on VRBO Prices updated March 2026

42 properties available

Lakefront Six Mile Vacation Rental w/ Dock

Lakefront Six Mile Vacation Rental w/ Dock

3 beds 3 baths
PoolA/CWiFiBalcony
$380/night
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Charming Lake Keowee Retreat, 16 miles from Clemson!

Charming Lake Keowee Retreat, 16 miles from Clemson!

2 beds 1 bath
PoolA/CWiFiBalcony
$237/night
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Clean, Modern, Lake Keowee Retreat Near Clemson

Clean, Modern, Lake Keowee Retreat Near Clemson

2 beds 1 bath
PoolA/CWiFiBalcony
$264/night
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THREE-LEVEL LAKEFRONT DESIGNER CHALET: ONLY 9 MILES FROM CLEMSON!

THREE-LEVEL LAKEFRONT DESIGNER CHALET: ONLY 9 MILES FROM CLEMSON!

3 beds 2 baths
PoolA/CWiFiBalcony
$469/night
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Welcome to our secluded and serene 2-bedroom, 2-bathroom chalet nestled on the private Murphree F...

Welcome to our secluded and serene 2-bedroom, 2-bathroom chalet nestled on the private Murphree F...

2 beds 2 baths
PoolA/CWiFiBalcony
$436/night
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Lake Keowee Escape w/ Dock, Deck & Lake Access!

Lake Keowee Escape w/ Dock, Deck & Lake Access!

3 beds 2 baths
PoolA/CWiFiBalcony
$347/night
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Relax LAKEFRONT: Incredible Panoramic Views & boat slip, 9 Miles to Clemson!

Relax LAKEFRONT: Incredible Panoramic Views & boat slip, 9 Miles to Clemson!

3 beds 3 baths
PoolA/CWiFiBalcony
$461/night
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Your perfect Lake Keowee getaway!

Your perfect Lake Keowee getaway!

4 beds 4 baths
PoolA/CWiFiBalcony
$577/night
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Lake Keowee Retreat with boat slip & lots of entertainment space near Clemson U

Lake Keowee Retreat with boat slip & lots of entertainment space near Clemson U

4 beds 3 baths
PoolA/CWiFiBalcony
$357/night
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Beautiful and spacious home near Warpath Landing with hot tub and dock!

Beautiful and spacious home near Warpath Landing with hot tub and dock!

5 beds 4 baths
PoolA/CWiFiBalcony
$1,182/night
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Lake Front Chalet 9.4 miles to Clemson University

Lake Front Chalet 9.4 miles to Clemson University

4 beds 3 baths
PoolA/CWiFiBalcony
$363/night
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Lakefront Cabin on Keowee with Private Dock

Lakefront Cabin on Keowee with Private Dock

3 beds 2 baths
PoolA/CWiFiBalcony
$432/night
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Amazing Mid Lake Keowee Location and Cove.

Amazing Mid Lake Keowee Location and Cove.

5 beds 3 baths
PoolA/CWiFiBalcony
$701/night
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Wonderful Gathering Spot for Large Families and Friends, 20 Minutes to Clemson

Wonderful Gathering Spot for Large Families and Friends, 20 Minutes to Clemson

6 beds 7 baths
PoolA/CWiFiBalcony
$1,402/night
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Enjoy your own slice of paradise on Lake Keowee. Cool water & amazing sunsets.

Enjoy your own slice of paradise on Lake Keowee. Cool water & amazing sunsets.

6 beds 4 baths
PoolA/CWiFiBalcony
$701/night
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Lake Keowee water front! Close to Clemson. Enjoy the new patio area w/ firepit

Lake Keowee water front! Close to Clemson. Enjoy the new patio area w/ firepit

4 beds 4 baths
PoolA/CWiFiBalcony
$395/night
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Waterfront home on Lake Keowee! Less than 10 miles to Clemson.

Waterfront home on Lake Keowee! Less than 10 miles to Clemson.

5 beds 3 baths
PoolA/CWiFiBalcony
$511/night
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Luxurious Rustic Log Home with Great Water Views and Sunsets!

Luxurious Rustic Log Home with Great Water Views and Sunsets!

6 beds 3 baths
PoolA/CWiFiBalcony
$747/night
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Waterfront Lake Keowee chalet with Gorgeous 180° Lake Views 15 min from Clemson!

Waterfront Lake Keowee chalet with Gorgeous 180° Lake Views 15 min from Clemson!

4 beds 3 baths
PoolA/CWiFiBalcony
$437/night
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Prime August weeks and weekends available!

Prime August weeks and weekends available!

5 beds 3 baths
PoolA/CWiFiBalcony
$544/night
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Stunning new construction Lake Keowee contemporary waterfront home!

Stunning new construction Lake Keowee contemporary waterfront home!

3 beds 2 baths
PoolA/CWiFiBalcony
$792/night
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Charming Lake Keowee Home with Private Dock

Charming Lake Keowee Home with Private Dock

4 beds 4 baths
PoolA/CWiFiBalcony
$560/night
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Harbour Pointe Chalet with Boat Slip

Harbour Pointe Chalet with Boat Slip

4 beds 3 baths
PoolA/CWiFiBalcony
$314/night
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Sunset Point on Lake Keowee

Sunset Point on Lake Keowee

5 beds 3 baths
PoolA/CWiFiBalcony
$620/night
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Pet-Friendly Keowee lakefront luxury home w/dock, 5BR, kayaks, stone fire pit

Pet-Friendly Keowee lakefront luxury home w/dock, 5BR, kayaks, stone fire pit

5 beds 4 baths
PoolA/CWiFiBalcony
$889/night
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Perfect Waterfront Lake Keowee Getaway with Hot tub

Perfect Waterfront Lake Keowee Getaway with Hot tub

5 beds 3 baths
PoolA/CWiFiBalcony
$701/night
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Water Front Cabin with Excellent Lake Views! near Clemson

Water Front Cabin with Excellent Lake Views! near Clemson

5 beds 3 baths
PoolA/CWiFiBalcony
$329/night
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Beautiful lake front house on Lake Keowee 12 miles from Clemson.

Beautiful lake front house on Lake Keowee 12 miles from Clemson.

6 beds 3 baths
PoolA/CWiFiBalcony
$801/night
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Sunset Cove on Lake Keowee

Sunset Cove on Lake Keowee

3 beds 1 bath
PoolA/CWiFiBalcony
$300/night
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Amazing Mountain, Lake and Private Island Views ~ Hot Tub ~ Kayaks ~ Pizza Oven!

Amazing Mountain, Lake and Private Island Views ~ Hot Tub ~ Kayaks ~ Pizza Oven!

5 beds 4 baths
PoolA/CWiFiBalcony
$1,501/night
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Clemson Football Game Weekends!

Clemson Football Game Weekends!

5 beds 3 baths
PoolA/CWiFiBalcony
$300/night
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Game Day Lake Retreat - Only 20 minutes to Clemson - Sunset views at Keowee

Game Day Lake Retreat - Only 20 minutes to Clemson - Sunset views at Keowee

3 beds 2 baths
PoolA/CWiFiBalcony
$165/night
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Rustic Lake Keowee Cabin, Perfect for Couples! Dock, Pool & Boat Slip

Rustic Lake Keowee Cabin, Perfect for Couples! Dock, Pool & Boat Slip

2 beds 1 bath
PoolA/CWiFiBalcony
$215/night
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Log Cabin On Lake Keowee-Big Lake Mountain Views

Log Cabin On Lake Keowee-Big Lake Mountain Views

3 beds 3 baths
PoolA/CWiFiBalcony
$404/night
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Welcome to our Lake Keowee Cottage Retreat in Six Mile! Escape to the tranquil beauty of Lake Keo...

Welcome to our Lake Keowee Cottage Retreat in Six Mile! Escape to the tranquil beauty of Lake Keo...

1 bed 1 bath
PoolA/CWiFiBalcony
$253/night
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Reunions, families, friends, long weekends, golfers, bikers & Clemson events.

Reunions, families, friends, long weekends, golfers, bikers & Clemson events.

6 beds 6 baths
PoolA/CWiFiBalcony
$1,201/night
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Dock Tales at Lake Keowee with private dock & game room

Dock Tales at Lake Keowee with private dock & game room

5 beds 3 baths
PoolA/CWiFiBalcony
$829/night
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Lakefront Six Mile Retreat w/ Hot Tub & Dock!

Lakefront Six Mile Retreat w/ Hot Tub & Dock!

4 beds 3 baths
PoolA/CWiFiBalcony
$376/night
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Waterfront Log Cabin on Lake Keowee

Waterfront Log Cabin on Lake Keowee

4 beds 3 baths
PoolA/CWiFiBalcony
$425/night
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Coveside Lane Getaway

Coveside Lane Getaway

5 beds 5 baths
PoolA/CWiFiBalcony
$956/night
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Paradise on Lake Keowee

Paradise on Lake Keowee

6 beds 6 baths
PoolA/CWiFiBalcony
$1,351/night
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Waterfront 5BD/5BA Dock & 9P-Hottub

Waterfront 5BD/5BA Dock & 9P-Hottub

5 beds 5 baths
PoolA/CWiFiBalcony
$1,068/night
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