Seneca, South Carolina

Vacation Rentals in Seneca, South Carolina

Discover 138 vacation rental properties in Seneca. From 1 to 10 bedrooms. Average $554/night. 100% have pools.

138 verified listings Book securely on VRBO Prices updated March 2026

138 properties available

June Discounted Rates! Waterfront Home w/ Covered Dock, 2 Decks, & Pet Friendly

June Discounted Rates! Waterfront Home w/ Covered Dock, 2 Decks, & Pet Friendly

4 beds 3 baths
PoolA/CWiFiBalcony
$221/night
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" Estate on the Lake" 7 BR/7 BA, 6 Suites, Over 8,400 Square Feet! Private Pool!

" Estate on the Lake" 7 BR/7 BA, 6 Suites, Over 8,400 Square Feet! Private Pool!

7 beds 6 baths
PoolA/CWiFiBalcony
$796/night
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Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks

Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks

5 beds 4 baths
PoolA/CWiFiBalcony
$471/night
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Quiet cove, minutes to Clemson, pet friendly

Quiet cove, minutes to Clemson, pet friendly

4 beds 2 baths
PoolA/CWiFiBalcony
$250/night
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Luxury Lake House on Lake Keowee

Luxury Lake House on Lake Keowee

4 beds 3 baths
PoolA/CWiFiBalcony
$721/night
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Fall fun at the cabin! Convenient to Lake Keowee and Clemson

Fall fun at the cabin! Convenient to Lake Keowee and Clemson

3 beds 1 bath
PoolA/CWiFiBalcony
$150/night
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Pirate's Retreat -Beautifully renovated lake home with Dock minutes from Clemson

Pirate's Retreat -Beautifully renovated lake home with Dock minutes from Clemson

3 beds 2 baths
PoolA/CWiFiBalcony
$400/night
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20% off June Specials!! 4BR Lakefront, Private Dock, 15min to Clemson

20% off June Specials!! 4BR Lakefront, Private Dock, 15min to Clemson

4 beds 3 baths
PoolA/CWiFiBalcony
$447/night
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Private lakefront home with dock & unbelievable sunsets on Lake Keowee

Private lakefront home with dock & unbelievable sunsets on Lake Keowee

3 beds 2 baths
PoolA/CWiFiBalcony
$479/night
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New! Peaceful Lakefront Home on Keowee! Only 7 Miles from Clemson!

New! Peaceful Lakefront Home on Keowee! Only 7 Miles from Clemson!

3 beds 3 baths
PoolA/CWiFiBalcony
$215/night
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Easy access lake front cancellation opening July 27-Aug 3 reduced rate

Easy access lake front cancellation opening July 27-Aug 3 reduced rate

6 beds 4 baths
PoolA/CWiFiBalcony
$425/night
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Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson

Serenity Bay, Keowee Lakefront Cabin, Covered Dock, Kayaks, Clean, Near Clemson

4 beds 3 baths
PoolA/CWiFiBalcony
$432/night
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Lakefront home with private beach & unbelievable sunsets on Lake Keowee

Lakefront home with private beach & unbelievable sunsets on Lake Keowee

3 beds 2 baths
PoolA/CWiFiBalcony
$466/night
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Best Lake Keowee Views and Private Boat Dock!

Best Lake Keowee Views and Private Boat Dock!

3 beds 2 baths
PoolA/CWiFiBalcony
$441/night
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Tranquil Lakefront Setting near Clemson SC with Private, Covered Dock

Tranquil Lakefront Setting near Clemson SC with Private, Covered Dock

3 beds 2 baths
PoolA/CWiFiBalcony
$286/night
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Seneca Lakefront Vacation Rental w/ Boat Dock!

Seneca Lakefront Vacation Rental w/ Boat Dock!

4 beds 3 baths
PoolA/CWiFiBalcony
$498/night
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Close to Mountains, Clemson, Asheville, Marina & Best Lake in the Carolinas

Close to Mountains, Clemson, Asheville, Marina & Best Lake in the Carolinas

4 beds 3 baths
PoolA/CWiFiBalcony
$339/night
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LAKE FRONT RETREAT! Steps Away from Swimming, Boating, Kayaking & Relaxing!

LAKE FRONT RETREAT! Steps Away from Swimming, Boating, Kayaking & Relaxing!

4 beds 2 baths
PoolA/CWiFiBalcony
$574/night
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Spacious Log Cabin on Point Lot, Private Beach, Boat and PWC Rental Available

Spacious Log Cabin on Point Lot, Private Beach, Boat and PWC Rental Available

5 beds 3 baths
PoolA/CWiFiBalcony
$681/night
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Bisquini Point at Lake Keowee

Bisquini Point at Lake Keowee

3 beds 2 baths
PoolA/CWiFiBalcony
$182/night
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Lakefront Keowee Luxury Cottages 127

Lakefront Keowee Luxury Cottages 127

3 beds 3 baths
PoolA/CWiFiBalcony
$411/night
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Lake Keowee Waterfront Home 15 miles from Clemson!

Lake Keowee Waterfront Home 15 miles from Clemson!

8 beds 4 baths
PoolA/CWiFiBalcony
$551/night
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South Carolina Retreat w/ Fireplace & Lake Access!

South Carolina Retreat w/ Fireplace & Lake Access!

4 beds 2 baths
PoolA/CWiFiBalcony
$382/night
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Amazing Waterfront Location on Lake Keowee!

Amazing Waterfront Location on Lake Keowee!

4 beds 3 baths
PoolA/CWiFiBalcony
$650/night
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Charming 4 bedroom/2bath Lakefront home convenient to Marina and Clemson!

Charming 4 bedroom/2bath Lakefront home convenient to Marina and Clemson!

4 beds 2 baths
PoolA/CWiFiBalcony
$357/night
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Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson

Beautiful Home on Lake Keowee- Deep Water Dock- 4bd/4ba -Close to Clemson

4 beds 4 baths
PoolA/CWiFiBalcony
$514/night
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Lake Keowee/Clemson Vacation Home for Family, Friends & Football WINTER DEALS!

Lake Keowee/Clemson Vacation Home for Family, Friends & Football WINTER DEALS!

3 beds 2 baths
PoolA/CWiFiBalcony
$512/night
View Details → Book on VRBO
Newly Updated Lake Keowee Property, just 10 miles from Clemson University

Newly Updated Lake Keowee Property, just 10 miles from Clemson University

5 beds 3 baths
PoolA/CWiFiBalcony
$652/night
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Life is Better at the Lake! Waterfront cabin on Lake Keowee

Life is Better at the Lake! Waterfront cabin on Lake Keowee

4 beds 2 baths
PoolA/CWiFiBalcony
$687/night
View Details → Book on VRBO
Beautiful Lake Keowee Home w/ Boat Dock & Kayaks

Beautiful Lake Keowee Home w/ Boat Dock & Kayaks

3 beds 3 baths
PoolA/CWiFiBalcony
$530/night
View Details → Book on VRBO
New 5BR Lakefront! Big water views, private dock, pool table, 15 min to Clemson!

New 5BR Lakefront! Big water views, private dock, pool table, 15 min to Clemson!

6 beds 4 baths
PoolA/CWiFiBalcony
$916/night
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Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

Beautiful waterfront home on a private cove in Lake Keowee w/ hot tub

7 beds 4 baths
PoolA/CWiFiBalcony
$493/night
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Lake Keowee waterfront gem! Private dock and lake views from every angle!

Lake Keowee waterfront gem! Private dock and lake views from every angle!

4 beds 2 baths
PoolA/CWiFiBalcony
$579/night
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Pristine views from Lakefront Home

Pristine views from Lakefront Home

4 beds 1 bath
PoolA/CWiFiBalcony
$530/night
View Details → Book on VRBO
Lake Keowee lakefront 4BR 3 bath home dock, screened porch, fire pit, tram

Lake Keowee lakefront 4BR 3 bath home dock, screened porch, fire pit, tram

4 beds 3 baths
PoolA/CWiFiBalcony
$356/night
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Incredible 10 BR home with pool and hot tub

Incredible 10 BR home with pool and hot tub

10 beds 10 baths
PoolA/CWiFiBalcony
$1,877/night
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Brand New Keowee Cottage w/Dock!

Brand New Keowee Cottage w/Dock!

4 beds 3 baths
PoolA/CWiFiBalcony
$414/night
View Details → Book on VRBO
Seneca Serenity. Huge Lake Front House. Discounted Summer Rates!

Seneca Serenity. Huge Lake Front House. Discounted Summer Rates!

7 beds 5 baths
PoolA/CWiFiBalcony
$917/night
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5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

5🌟 Modern Lakefront Luxury Oasis 🇺🇸 270° Lake Views w/Dock & Hot Tub!

7 beds 8 baths
PoolA/CWiFiBalcony
$1,156/night
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Large family home with dock on Lake Keowee!

Large family home with dock on Lake Keowee!

7 beds 5 baths
PoolA/CWiFiBalcony
$751/night
View Details → Book on VRBO
Kate's Kayak Cove on Lake Keowee!

Kate's Kayak Cove on Lake Keowee!

3 beds 2 baths
PoolA/CWiFiBalcony
$632/night
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500 FT OF DEEP WATER FRONTAGE ON THE BEAUTIFUL EMRALD COLOR WATER OF LAKE KEOWEE

500 FT OF DEEP WATER FRONTAGE ON THE BEAUTIFUL EMRALD COLOR WATER OF LAKE KEOWEE

4 beds 3 baths
PoolA/CWiFiBalcony
$726/night
View Details → Book on VRBO
Lake House Getaway with Heated Pool & Dock & Pet Friendly!

Lake House Getaway with Heated Pool & Dock & Pet Friendly!

5 beds 3 baths
PoolA/CWiFiBalcony
$759/night
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Serenity Bay Lakehouse

Serenity Bay Lakehouse

4 beds 3 baths
PoolA/CWiFiBalcony
$455/night
View Details → Book on VRBO
Just steps to the Crisp & Clear waters of Lake Keowee and close to Clemson

Just steps to the Crisp & Clear waters of Lake Keowee and close to Clemson

4 beds 3 baths
PoolA/CWiFiBalcony
$376/night
View Details → Book on VRBO
Lake Keowee Waterfront Town Home - 3 Bdrm, 3.5 Bath 7 Miles from Clemson Stadium

Lake Keowee Waterfront Town Home - 3 Bdrm, 3.5 Bath 7 Miles from Clemson Stadium

3 beds 3 baths
PoolA/CWiFiBalcony
$408/night
View Details → Book on VRBO
Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!

Lakefront Cabin on Lake Keowee. Kayaks, paddle boards, modern & cozy!

5 beds 4 baths
PoolA/CWiFiBalcony
$648/night
View Details → Book on VRBO
June Specials 20% off! 4BR Lakefront, Private Dock, Huge views! 15min to Clemson

June Specials 20% off! 4BR Lakefront, Private Dock, Huge views! 15min to Clemson

4 beds 2 baths
PoolA/CWiFiBalcony
$518/night
View Details → Book on VRBO

Showing 48 of 138 properties

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