Santee, South Carolina

Vacation Rentals in Santee, South Carolina

Discover 50 vacation rental properties in Santee. From 2 to 4 bedrooms. Average $275/night. 100% have pools.

50 verified listings Book securely on VRBO Prices updated March 2026

50 properties available

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

3 beds 2 baths
PoolA/CWiFiBalcony
$168/night
View Details → Book on VRBO
Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available

Waterfront 3 Bedroom / 3 Bath Condo w/ Boat Slip Available

3 beds 3 baths
PoolA/CWiFiBalcony
$180/night
View Details → Book on VRBO
Lovely Condo w/pool, balcony, and lakeside view!

Lovely Condo w/pool, balcony, and lakeside view!

2 beds 2 baths
PoolA/CWiFiBalcony
$103/night
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Lake Marion - Majestic Big Water View!

Lake Marion - Majestic Big Water View!

2 beds 2 baths
PoolA/CWiFiBalcony
$206/night
View Details → Book on VRBO
Waterfront Condo 3BR/3BA- Lake Marion, Ballards Point II, Santee, SC

Waterfront Condo 3BR/3BA- Lake Marion, Ballards Point II, Santee, SC

3 beds 3 baths
PoolA/CWiFiBalcony
$170/night
View Details → Book on VRBO
Executive 2 BR/2 BA Lakefront Corner Suite Condo

Executive 2 BR/2 BA Lakefront Corner Suite Condo

2 beds 2 baths
PoolA/CWiFiBalcony
$187/night
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Sunsets on Lake Marion: 2BD Lakefront Luxury Bliss

Sunsets on Lake Marion: 2BD Lakefront Luxury Bliss

2 beds 2 baths
PoolA/CWiFiBalcony
$135/night
View Details → Book on VRBO
Lakeside vacationing close to golf courses, restaurants and boat rental company!

Lakeside vacationing close to golf courses, restaurants and boat rental company!

3 beds 3 baths
PoolA/CWiFiBalcony
$216/night
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Waterfront Condo on Lake Marion

Waterfront Condo on Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$348/night
View Details → Book on VRBO
Serenity at Santee

Serenity at Santee

2 beds 2 baths
PoolA/CWiFiBalcony
$236/night
View Details → Book on VRBO
Fully renovated 1959 lake front cottage. In-ground swimming pool and spa.

Fully renovated 1959 lake front cottage. In-ground swimming pool and spa.

4 beds 2 baths
PoolA/CWiFiBalcony
$486/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$249/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$244/night
View Details → Book on VRBO
Lake Side Condo Getaway

Lake Side Condo Getaway

2 beds 2 baths
PoolA/CWiFiBalcony
$197/night
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Two Palms Lakehouse in Santee Just minutes from I95

Two Palms Lakehouse in Santee Just minutes from I95

4 beds 2 baths
PoolA/CWiFiBalcony
$300/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$315/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$249/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$249/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$249/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$315/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$240/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$240/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$240/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$240/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$240/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$244/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$244/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$244/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$244/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$296/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$296/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$296/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$296/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$296/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$305/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$307/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$305/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$305/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$305/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$315/night
View Details → Book on VRBO
Fisheagle Nature Adventures, Golf Courses, Santee State Park

Fisheagle Nature Adventures, Golf Courses, Santee State Park

2 beds 2 baths
PoolA/CWiFiBalcony
$570/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$249/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$249/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$315/night
View Details → Book on VRBO
Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

Lakeside Bliss: 3BR Suite at Wyndham Lake Marion

3 beds 3 baths
PoolA/CWiFiBalcony
$315/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$249/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$249/night
View Details → Book on VRBO
Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

Lakeside Bliss: 2BR Suite at Wyndham Lake Marion

2 beds 2 baths
PoolA/CWiFiBalcony
$249/night
View Details → Book on VRBO

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